Serving all people by providing personalized health and wellness through exemplary care, education and research.
Explore health content from A to Z.
I need information about...
Neuronal and mixed neuronal-glial tumors are a group of rare tumors that occur in the brain or spinal cord. Together, your brain and spinal cord make up your central nervous system (CNS). Many of these tumors are not cancerous (benign). Benign means that the growth does not spread to other parts of the body. However, these tumors can be dangerous because they can cause seizures or other problems by pressing against surrounding brain tissue.
Your brain and spinal cord contain many neurons and other supporting cells (such as glial cells). The neurons are specialized nerve cells that send messages within the CNS and the rest of your body. These neurons “talk” to each other by using chemical and electrical signals. Glial cells do not send nerve signals but carry out many other jobs in your brain, such as insulating and providing support to the neurons.
A tumor is an abnormal growth of cells. Most brain tumors come from the glial cells or other non-neuronal cells in the CNS. Neuronal tumors are a rare group of brain tumors made of abnormal neurons. Mixed neuronal-glial tumors are a rare group of brain tumors that have abnormal neuron cells in addition to glial cells.
Doctors who specialize in examining tumor cells under a microscope normally grade them on a scale from I to IV. Grading is based on how abnormal the cells look. The cells from a grade I tumor look almost normal and grow slowly, while a grade IV tumor tends to grow very quickly.
Most neuronal and mixed neuronal-glial tumors are low grade (grade I or II) and tend to grow slowly. The cells look almost normal. Doctors often remove low-grade tumors surgically.
There is one subtype of neuronal tumor that is grade III. It is called anaplastic ganglioglioma. This type tends to grow more quickly than most other neuronal tumors. It may need more aggressive treatment with chemotherapy and radiation in addition to surgery.
Overall, neuronal and mixed neuronal-glial tumors tend to be slow growing.
Some neuronal and mixed neuronal-glial tumors happen more often in children or teens than in adults. Other types (such as the cerebellar liponeurocytoma) are more common in older adults. Almost any of these tumors can occur in people of any age.
Experts do not yet know what causes neuronal and mixed neuronal-glial tumors to develop. Some theories suggest links to gene mutations, environmental toxins, or infections (such as by viruses). However, the possible risk factors for these tumors are not clear.
Where the tumor is located in the brain and its size determine what symptoms you may have. A neuronal or a mixed neuronal-glial tumor may cause symptoms related to the part of the brain that it grows in.
In general, some symptoms of a neuronal or a mixed neuronal-glial tumor may include:
Doctors usually take a medical history, and ask about your recent symptoms, past medical conditions, and your family medical history. You will need a thorough physical exam, including a neurologic exam. Your doctor will likely assess your coordination and reflexes and do several neurologic tests. If a doctor suspects a brain tumor, he or she will typically want to look at medical images of your brain. You may need:
You may first see your primary healthcare provider and then get a referral to a specialist. This doctor should be an expert in diagnosing and treating diseases of the brain, such as a neurologist, neurosurgeon, or neuro-oncologist.
The standard treatment for these tumors is to remove them surgically. In many cases, treatment may only consist of removal of the tumor. If the tumor is in a spot where it is not possible to remove it completely, radiation therapy and chemotherapy are other options.
You can work with your medical team to discuss the best treatment plan for you. You will probably need regular follow-up with your doctor, including repeated imaging tests to check whether the tumor comes back. It is very important to keep follow-up appointments so that your medical team can monitor any changes.
Seizures are the most common neurologic symptoms. In some cases, the tumor may be blocking drainage of the cerebrospinal fluid from your brain. This causes a buildup of fluid and increases the pressure within your brain. If this happens, you may need surgery to insert a tube to drain excess fluid and lower your intracranial pressure. After removal of the tumor, this problem usually goes away.
There is the possibility of the tumor growing back if you don’t have it removed completely. In very rare instances, a tumor might change into a higher-grade form.
Neuronal and mixed neuronal-glial tumors are rare tumors of the brain or spinal cord. These tumors include abnormal nerve cells. Some key points include:
Tips to help you get the most from a visit to your healthcare provider:
Copyright © 2017 Baylor Scott & White Health. All Rights Reserved. |
3500 Gaston Ave., Dallas, TX 75246-2017 | 1.800.4BAYLOR