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Kidney Cancer: Chemotherapy

What is chemotherapy?

Photo of intravenous drug bag

Chemotherapy uses anticancer medicines to kill cancer cells. The medicines are made to attack and kill cancer cells that grow quickly.

Some normal cells also grow quickly. Because of this, chemotherapy can also harm those cells. This can cause side effects.

How chemotherapy given for kidney cancer?

Chemotherapy medicine is most often given through an IV. It may also be taken by mouth as a pill, or as an injection. The treatment may be done as an outpatient visit to a hospital, and you go home the same day. Or it may be at your healthcare provider’s office, a chemotherapy clinic, or at home. In some cases, you may stay in the hospital during treatment.

If you need to have an IV for each cycle of chemotherapy, it can be helpful to have a vein (venous) access device or an indwelling catheter. A catheter is a thin, flexible tube. The catheter would stay in place between cycles so that you don't have a new IV started each time you get treatment.

One end of the tube is placed into a vein near your heart. The other end is placed just under the skin or comes out through the skin. The chemotherapy can then be connected to it when you have treatment. Your healthcare team will talk with you about the risks and benefits a venous access device or indwelling catheter.

Chemotherapy in cycles

You get chemotherapy in cycles over a period of time. That means you may take the medicine for a set amount of time and then you have a rest period. Each period of treatment and rest is one cycle. You may have several cycles. Having treatment in cycles helps by:                                                           

  • Killing more cancer cells. The medicine can kill more cancer cells over time, because cells aren't all dividing at the same time. Cycles allow the medicine to fight more cells.

  • Giving your body a rest. Treatment is hard on other cells of the body that divide quickly. This includes cells in the lining of the mouth and stomach. This causes side effects, such as sores and nausea. Between cycles, your body can get a rest from the chemotherapy.

  • Giving your mind a rest. Having chemotherapy can be stressful. Taking breaks between cycles can let you get an emotional break between treatments.

What types of medicines are used to treat kidney cancer?

Some of the chemotherapy medicines that might be used include:   

  • Gemcitabine

  • 5-fluorouracil (5-FU)

  • Capecitabine

  • Vinblastine

  • Floxuridine

You may take more than one medicine. This is called combination therapy. Which medicines you get and how often you get them depend on many factors. If you have chemotherapy, you may have it along with biologic therapy.

What are common side effects of chemotherapy?                 

Side effects are common with chemotherapy, but it's important to know that they can often be prevented or controlled. The side effects from chemotherapy usually go away when the treatment ends. Side effects of chemotherapy depend on the type and amount of medicines you’re taking. They vary from person to person.                                           

Some common temporary side effects from chemotherapy include:

  • Nausea and vomiting

  • Mouth sores 

  • Constipation or diarrhea 

  • Hair loss

  • Infections from low white blood cell counts

  • Easy bruising or bleeding from low blood platelets  

  • Tiredness from low red blood cell counts

  • Loss of appetite

  • Dizziness

  • Skin problems, such as dryness, rash, blistering, or darkening skin

  • Tingling, numbness, or swelling in hands or feet

Most of side effects will go away or get better between treatments and a few weeks after treatment ends. You may also be able to help control some of these side effects. Tell your healthcare providers about any side effects you have. They can help you cope with the side effects.

Working with your healthcare provider

It's important to know which medicines you're taking. Write your medicines down, and ask your healthcare team how they work and what side effects they might have.

Talk with your healthcare providers about what signs to look for and when to call them. For example, chemotherapy can make you more likely to get infections.  Make sure you know what number to call with questions. Is there a different number for evenings and weekends?

It may be helpful to keep a diary of your side effects. Write down physical, thinking, and emotional changes. A written list will make it easier for you to remember your questions when you go to your appointments. It will also make it easier for you to work with your healthcare team to make a plan to manage your side effects. 

Online Medical Reviewer: MMI board-certified, academically affiliated clinician
Online Medical Reviewer: Stump-Sutliff, Kim, RN, MSN, AOCNS
Last Review Date: 3/17/2015
© 2013 The StayWell Company, LLC. 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare provider's instructions.