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Endometrial Cancer: Risk Factors

What is a risk factor?

A risk factor is anything that may increase your chance of having a disease. Risk factors for a certain type of cancer might include smoking, diet, family history, or many other things. The exact cause of someone’s cancer may not be known. But risk factors can make it more likely for a person to have cancer. 

Things you should know about risk factors for cancer: 

  • Risk factors can increase a person's risk, but they do not necessarily cause the disease.

  • Some people with 1 or more risk factors never develop cancer. Other people can develop cancer and have no risk factors.

  • Some risk factors are very well known. But there is ongoing research about risk factors for many types of cancer.

 Some risk factors, such as family history, may not be in your control. But others may be things you can change. Knowing the risk factors can help you make choices that might lower your risk. For example, if an unhealthy diet is a risk factor, you may choose to eat healthy foods. If excess weight is a risk factor, your healthcare provider may check your weight or help you lose weight.

Who is at risk for endometrial cancer?

Risk factors for endometrial cancer include:

  • High blood pressure

  • Diabetes

  • Diet high in animal fats

  • Not being physically active

  • Family history of endometrial cancer

  • Family history of colon cancer (hereditary nonpolyposis colon cancer)

  • Personal history of breast cancer

  • Personal history of ovarian cancer

  • Prior radiation therapy for pelvic cancer

  • Personal history of atypical endometrial hyperplasia

  • Older age

Most of the risk factors linked to endometrial cancer come from too much exposure to the hormone estrogen. Estrogen and progesterone are the two main types of female hormones. The balance between these two hormones in your uterus changes every month during your menstrual cycle. These two hormones need to be in the right balance for your uterus to be healthy. Risk factors that can affect this hormone balance and can increase your risk for endometrial cancer include:

  • Obesity

  • Late menopause

  • Starting monthly periods before age 12

  • Inability to become pregnant (infertility)

  • Not giving birth to any children

  • Being treated with tamoxifen for breast cancer

  • Use of estrogen replacement therapy (ERT) to treat menopause symptoms

  • Personal history of polycystic ovary syndrome

  • Personal history of a type of ovarian tumor called a granulosa cell tumor

What are your risk factors?

Talk with your healthcare provider about your risk factors for endometrial cancer and what you can do about them. For instance, you may be able to lower your risk in areas you can control, such as diet and exercise. In fact, you can make some general lifestyle changes to reduce your endometrial cancer risk:  

  • Eat a healthy diet and stay at a healthy weight. Limit the fat in your diet. Eat a moderate amount of a variety of foods. Get regular physical activity. If you have diabetes or high blood pressure, work with your healthcare team to manage your condition. Your plan may include diet, exercise, and medicine. These steps will all help keep your weight within a healthy range.

  • Monitor and treat endometrial hyperplasia. If you have precancerous changes of the endometrium, talk to your doctor. You may need screening tests to check on the changes. Or you may need treatment.

  • Review your hormone therapy strategy. If you've gone through menopause and use estrogen therapy to help deal with the changes in your body, use the lowest dose possible for the shortest amount of time. Talk with your doctor about taking progesterone along with estrogen. Using just estrogen without progesterone can lead to endometrial cancer if you still have your uterus. If your symptoms of menopause have gone away or gotten better, you may be able to reduce or stop hormone therapy.



Online Medical Reviewer: Akin, Louise, RN
Online Medical Reviewer: Stump-Sutliff, Kim, RN, MSN, AOCNS
Last Review Date: 7/31/2015
© 2013 The StayWell Company, LLC. 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare provider's instructions.