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Understanding PMS and Your Cycle

PMS (premenstrual syndrome) is a real condition caused by the body’s response to a normal menstrual cycle. The menstrual cycle is brought on by changing levels of hormones (chemical messengers) in the body. In some women, normal hormone changes are linked to decreases in serotonin, a brain chemical that improves mood. These changes lead to PMS symptoms each month.

The Menstrual Cycle

During the menstrual cycle, a series of hormone changes prepare a woman’s body for pregnancy. The ovaries make hormones, which include estrogen and progesterone. Throughout the cycle, the levels of these hormones change. This causes the lining of the uterus (womb) to thicken. Hormone changes also lead to ovulation (release of an egg). If a woman doesn’t become pregnant, her body sheds the thickened lining and the egg during the menstrual period. For many women, the menstrual cycle lasts 4 weeks (28 days). Some women have shorter cycles. Others have longer ones. No matter how many days your cycle is, you can have PMS only if you ovulate.

The PMS Cycle

No one knows why some women have PMS and others don’t. But PMS symptoms are closely linked to changing levels of estrogen, serotonin, and progesterone.

  • Estrogen rises during the first half of the menstrual cycle and drops during the second half. In some women, serotonin levels stay mostly steady. But in women with PMS, serotonin drops as estrogen drops. This means serotonin is lowest in the 2 weeks before the period. Women with low serotonin levels are likely to have symptoms of PMS.

  • Progesterone can have a “calming” effect on the body. This can ease physical symptoms caused by the body’s monthly changes. In women with PMS, progesterone may not have this calming effect. This may make symptoms more severe.

Common Symptoms of PMS

Physical Symptoms

  • Bloating (retaining water)

  • Breast tenderness

  • Food cravings

  • Muscle aches

  • Swelling of hands and feet

  • Appetite changes

  • Headache

  • Feeling tired

Emotional Symptoms

  • Mood swings

  • Depression

  • Crying spells

  • Irritability

  • Oversensitivity

  • Withdrawing from friends and family

  • Forgetfulness

  • Having trouble concentrating

Online Medical Reviewer: Eder, Scott Evan, MD, FACOG, FACS
Online Medical Reviewer: Joseph, Marilyn S, MD, FACOG
Last Review Date: 3/1/2012
© 2000-2014 Krames StayWell, 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.