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Isradipine Oral tablet, extended-release

What is this medicine?

ISRADIPINE (iz RA di peen) is a calcium-channel blocker. It affects the amount of calcium found in your heart and muscle cells. This relaxes your blood vessels, which can reduce the amount of work the heart has to do. This medicine is used to lower high blood pressure.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Swallow whole. Do not crush, break, or chew. This medicine may be taken with or without food. Take your doses at regular intervals. Do not take your medicine more often then directed. Do not suddenly stop taking this medicine. Ask your doctor or health care professional how you can gradually reduce the dose.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • difficulty breathing

  • dizziness or drowsiness

  • fainting spells, lightheadedness

  • fast heartbeat, palpitations, irregular heartbeat, chest pain

  • swelling of the legs and ankles

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • facial flushing

  • headache

  • weakness or tiredness

What may interact with this medicine?

  • fentanyl

  • grapefruit juice

  • propranolol

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Protect from moisture and humidity. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • heart problems, low blood pressure, slow or irregular heartbeat

  • liver disease

  • previous heart attack

  • an unusual or allergic reaction to isradipine, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups. Check your blood pressure and pulse rate regularly. Ask your health care professional what your blood pressure and pulse rate should be, and when you should contact him or her.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Online Medical Reviewer: Louise Akin, RN, BSN
Online Medical Reviewer: Daphne Pierce-Smith, RN, MSN, FNP, CCRC
Last Review Date: 6/10/2009
© 2000-2014 Krames StayWell, 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.