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DROSPIRENONE; ESTRADIOL (dro SPY re nown; es tra DYE ole) is used as hormone replacement in menopausal women who still have their uterus. This medicine is used to treat some of the symptoms of menopause like hot flashes and vaginal dryness.
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine at the same time each day. Do not take your medicine more often than directed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breast tissue changes or discharge
changes in vision
feeling faint or lightheaded, falls
high blood pressure
leg, arm or groin pain
problems with balance, talking, walking
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
change in appetite
changes in sexual desire
mood changes, anxiety, depression, frustration, anger, or emotional outbursts
nausea, stomach upset
skin rash, acne, or brown spots on the skin
vaginal itching, irritation or discharge
Do not take this medicine with any of the following medications:
aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
antiviral medicines for HIV or AIDS
certain antibiotics like clarithromycin, erythromycin, rifampin, rifabutin, rifapentine, and possibly penicillins or tetracyclines
certain diuretics like amiloride, spironolactone, triamterene
certain medicines for fungal infections like griseofulvin, ketoconazole, itraconazole
certain medications for high blood pressure or heart conditions like ACE-inhibitors, Angiotensin-II receptor blockers, eplerenone
certain medicines for seizures like carbamazepine, oxcarbazepine, phenobarbital, phenytoin
corticosteroid like hydrocortisone and prednisolone
medicines for diabetes, including pioglitazone
St. John's wort
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
blood vessel disease or blood clots
breast, cervical, endometrial, or uterine cancer
heart disease or recent heart attack
high blood cholesterol
high level of calcium in the blood
systemic lupus erythematosus (SLE)
an unusual or allergic reaction to estrogens, progestins, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your health care professional for regular checks on your progress. You should have a complete check-up every 6 months. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.
Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.
If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.
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