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DONEPEZIL (doe NEP e zil) is used to treat mild to moderate dementia caused by Alzheimer's disease.
Take this medicine by mouth. Follow the directions on the prescription label. Place the tablet in the mouth and allow it to dissolve, then swallow. While you may take these tablets with water, it is not necessary to do so. You may take this medicine with or without food. Take your doses at regular intervals. This medicine is usually taken before bedtime. Do not take your medicine more often than directed. Continue to take your medicine even if you feel better. Do not stop taking except on the advice of your doctor or health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
feeling faint or lightheaded, falls
loss of bladder control
signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast or irregular heartbeat; palpitations; feeling faint or lightheaded, falls; breathing problems
signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine
signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
slow heartbeat or palpitations
unusual bleeding or bruising
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
diarrhea, especially when starting treatment
loss of appetite
Do not take this medicine with any of the following medications:
certain medicines for fungal infections like itraconazole, fluconazole, posaconazole, and voriconazole
This medicine may also interact with the following medications:
antihistamines for allergy, cough and cold
certain medicines for bladder problems like oxybutynin, tolterodine
certain medicines for Parkinson's disease like benztropine, trihexyphenidyl
certain medicines for stomach problems like dicyclomine, hyoscyamine
certain medicines for travel sickness like scopolamine
NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
other medicines for Alzheimer's disease
other medicines that prolong the QT interval (cause an abnormal heart rhythm)
rifampin, rifabutin or rifapentine
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
asthma or other lung disease
difficulty passing urine
history of irregular heartbeat
stomach or intestinal disease, ulcers or stomach bleeding
an unusual or allergic reaction to donepezil, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your doctor or health care professional for regular checks on your progress. Check with your doctor or health care professional if your symptoms do not get better or if they get worse.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you.
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