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ESTRADIOL (es tra DYE ole) contains the female hormone estrogen. It is used for symptoms of menopause like hot flashes, night sweats, and mood changes. This medicine may also help relieve other symptoms like vaginal dryness, itching and increased or painful urination.
This medicine is for external use only. Follow the directions that come with your prescription. Spread the gel into a thin layer. It is not necessary to rub or massage the gel into the skin. Wash your hands with soap and water after applying the gel. Allow the gel to dry for up to 5 minutes before dressing. Avoid fire, flame or smoking until gel has dried. Do not apply to the breast, face or in or around the vagina. Do not use your medicine more often than directed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
breakthrough bleeding and spotting
breast tissue changes or discharge
leg, arm or groin pain
stomach pain (severe)
sudden shortness of breath
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
changes in emotions or mood
changes in sex drive or performance
increased or decreased appetite
skin rash, acne, or brown spots on the skin
symptoms of vaginal infection like itching, irritation or unusual discharge
Do not take this medicine with any of the following medications:
aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
antibiotics used to treat tuberculosis like rifabutin, rifampin and rifapentine
raloxifene or tamoxifen
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
abnormal vaginal bleeding
blood vessel disease or blood clots
breast, cervical, endometrial, ovarian, liver, or uterine cancer
heart disease or recent heart attack
high blood pressure
high level of calcium in the blood
protein C deficiency
protein S deficiency
systemic lupus erythematosus (SLE)
an unusual or allergic reaction to estrogens, other hormones, soy, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.
Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.
If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.
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