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APOMORPHINE (a poe MOR feen) is used to treat 'off' episodes in advanced Parkinson's disease. These episodes affect your ability to move or perform tasks.
This medicine is for injection under the skin. You will be taught how to prepare and give this medicine. You will also need to take a medicine prescribed by your doctor to prevent nausea and vomiting when you first start treatment. Use exactly as directed. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice. Stopping this medicine too quickly may cause serious side effects.
It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
falling asleep during normal activities like driving
feeling faint or lightheaded, falls
hallucination, loss of contact with reality
males: prolonged or painful erection
signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast or irregular heartbeat; palpitations; feeling faint or lightheaded, falls; breathing problems
signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired
swelling in arms, hands, legs, or feet
uncontrollable and excessive urges (examples: gambling, binge eating, shopping, having sex)
uncontrollable head, mouth, neck, arm, or leg movements
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome)
pain, redness, or irritation at site where injected
Do not take this medicine with any of the following medications:
certain antibiotics like grepafloxacin and sparfloxacin
medicines for irregular heart beat like amiodarone, disopyramide, dofetilide, flecainide, ibutilide, procainamide, quinidine, sotalol
some medicines for nausea like alosetron, dolasetron, dronabinol, droperidol, granisetron, ondansetron, palonosetron
This medicine may also interact with the following medications:
certain antibiotics like clarithromycin, erythromycin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, troleandomycin
medicines for high blood pressure or chest pain (angina)
medicines to treat or prevent malaria like chloroquine or mefloquine
phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
some medicines for depression like amitriptyline, amoxapine, maprotiline, mirtazapine, nefazodone, nortriptyline
some medicines for mental disturbances like clozapine, haloperidol, molindone, olanzapine, pimozide, quetiapine, risperidone, ziprasidone
This does not apply. This medicine is only given as needed to treat 'off' episodes in Parkinson's disease. Contact your health care provider if your symptoms do not respond to the first dose for a particular 'off' episode. Do not use a second dose for that episode. Do not use double or extra doses.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees). Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
asthma or other breathing problems
history of alcohol or drug abuse
kidney or liver disease
low blood pressure
an unusual or allergic reaction to apomorphine, sulfites, other medicines foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your doctor or health care professional for regular checks on your progress.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. This medicine may cause a sudden drop in blood pressure with or without symptoms such as nausea, dizziness, feeling faint, or sweating, especially when you first start treatment or after an increase in dose. Do not get up too quickly from a lying or sitting position. A drop in blood pressure may increase the risk for falling. Report any dizziness or related symptoms to your health care provider as soon as possible. Limit alcoholic drinks. Alcohol may increase the risk of dizziness and drowsiness. Do not take any medications that cause drowsiness without first checking with your health care provider.
If you find that you have sudden feelings of wanting to sleep during normal activities, like cooking, watching television, or while driving or riding in a car, you should contact your health care professional.
This medicine may cause severe nausea and vomiting. Your doctor may prescribe a medication to prevent these symptoms. Do not treat yourself. Not all medicines for nausea and vomiting can be used with this medicine. Talk to your doctor about which one may be right for you.
There have been reports of increased sexual urges or other strong urges such as gambling while taking some medicines for Parkinson's disease. If you experience any of these urges while taking this medicine, you should report it to your health care provider as soon as possible.
You should check your skin often for changes to moles and new growths while taking this medicine. Call your doctor if you notice any of these changes.
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