Need something? Call us: 1.800.4BAYLOR(1.800.422.9567)
Text Size:

Tolcapone Oral tablet

What is this medicine?

TOLCAPONE (TOLE ka pone) is used in combination with levodopa-carbidopa therapy to treat Parkinson's disease.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take this medicine with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • confusion

  • dark urine

  • feeling faint or lightheaded

  • fever

  • general ill feeling or flu-like symptoms

  • hallucinations

  • involuntary muscle movements

  • light-colored stools

  • loss of appetite, nausea

  • right upper belly pain

  • severe diarrhea

  • unusually weak or tired

  • yellowing of eyes, skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation

  • headache

  • increased sweating

  • muscle cramping

  • stomach upset

  • trouble sleeping

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • isoniazid

  • medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl

  • procarbazine

This medicine may also interact with the following medications:

  • apomorphine

  • dobutamine

  • isoproterenol

  • methyldopa

  • phenelzine

  • warfarin

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • kidney disease

  • liver disease

  • severe movement disorder

  • an unusual or allergic reaction to tolcapone, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor for regular check ups. You will need to have important blood work done while you are taking this medicine. Tell your doctor if your symptoms do not get better or if they get worse.

You may get dizzy or have difficulty controlling your movements. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase possible dizziness. Avoid alcoholic drinks.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

There have been reports of increased sexual urges or other strong urges such as gambling while taking some medicines for Parkinson's disease. If you experience any of these urges while taking this medicine, you should report it to your health care provider as soon as possible.

You should check your skin often for changes to moles and new growths while taking this medicine. Call your doctor if you notice any of these changes.

Online Medical Reviewer: Louise Akin, RN, BSN
Online Medical Reviewer: Daphne Pierce-Smith, RN, MSN, FNP, CCRC
Last Review Date: 9/3/2009
© 2000-2014 Krames StayWell, 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.