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ESTRADIOL (es tra DYE ole) contains the female hormone estrogen. It is used for symptoms of menopause, like vaginal dryness and irritation.
This medicine is for use in the vagina only. Do not take by mouth. Follow the directions on the prescription label. Read package directions carefully before using. Use the special applicator supplied with the cream. Wash hands before and after use. Fill the applicator with the prescribed amount of cream. Lie on your back, part and bend your knees. Insert the applicator into the vagina and push the plunger to expel the cream into the vagina. Wash the applicator with warm soapy water and rinse well. Use exactly as directed for the complete length of time prescribed. Do not stop using except on the advice of your doctor or health care professional.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breast tissue changes or discharge
changes in vision
confusion, trouble speaking or understanding
general ill feeling or flu-like symptoms
pain, swelling, warmth in the leg
right upper belly pain
shortness of breath
sudden numbness or weakness of the face, arm or leg
trouble walking, dizziness, loss of balance or coordination
unusual vaginal bleeding
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
increased hunger or thirst
symptoms of vaginal infection like itching, irritation or unusual discharge
unusually weak or tired
Do not take this medicine with any of the following medications:
aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
barbiturates used for inducing sleep or treating seizures
medicines for fungal infections like ketoconazole and itraconazole
some antibiotics used to treat infections
St. John's Wort
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from temperatures above 40 degrees C (104 degrees C). Do not freeze. Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
abnormal vaginal bleeding
blood vessel disease or blood clots
breast, cervical, endometrial, ovarian, liver, or uterine cancer
heart disease or recent heart attack
high blood pressure
high levels of calcium in the blood
protein C deficiency
protein S deficiency
systemic lupus erythematosus (SLE)
an unusual or allergic reaction to estrogens, other hormones, soy, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medicine at once and contact your doctor or health care professional.
Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.
If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.
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