Need something? Call us: 1.800.4BAYLOR(1.800.422.9567)
Text Size:

Conjugated Estrogens Vaginal cream

What is this medicine?

CONJUGATED ESTROGENS (CON ju gate ed ESS troe jenz) are a mixture of female hormones. This cream can help relieve symptoms associated with menopause.like vaginal dryness and irritation.

How should I use this medicine?

This medicine is for use in the vagina only. Do not take by mouth. Follow the directions on the prescription label. Use at bedtime unless otherwise directed by your doctor or health care professional. Use the special applicator supplied with the cream. Wash hands before and after use. Fill the applicator with the cream and remove from the tube. Lie on your back, part and bend your knees. Insert the applicator into the vagina and push the plunger to expel the cream into the vagina. Wash the applicator with warm soapy water and rinse well. Use exactly as directed for the complete length of time prescribed. Do not stop using except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • unusually weak or tired

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • barbiturates used for inducing sleep or treating seizures

  • carbamazepine

  • grapefruit juice

  • medicines for fungal infections like itraconazole and ketoconazole

  • raloxifene or tamoxifen

  • rifabutin

  • rifampin

  • rifapentine

  • ritonavir

  • some antibiotics used to treat infections

  • St. John's Wort

  • warfarin

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high level of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.

Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.

If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.

Online Medical Reviewer: Louise Akin, RN, BSN
Online Medical Reviewer: Daphne Pierce-Smith, RN, MSN, FNP, CCRC
Last Review Date: 3/21/2012
© 2000-2014 The StayWell Company, LLC. 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.